Antidiuretic hormone (ADH; vasopressin) is a hormone produced in the hypothalamus of the brain. It concentrates the urine by triggering the kidneys to reabsorb water into the blood stream rather than excreting water into the urine.

Nephrogenic diabetes insipidus involves a defect in the kidney tubules (the portion of the kidneys that causes water to be excreted or reabsorbed).

The specific kidney defect is usually a partial or complete failure of special receptors located on or within the kidney tubules to respond to ADH, the hormone that transmits the instruction to concentrate the urine to the inside of the cells.

Excessive amounts of water are excreted with the urine, producing a large quantity of very dilute urine. There is little or no response to vasopressin, even though the blood level of this hormone is higher than normal.

If thirst mechanisms are normal and adequate fluids are consumed, there are no significant effects on the fluid and/or electrolyte balance of the body. If inadequate fluids are consumed, the high urine output may cause dehydration and high blood sodium.

Nephrogenic diabetes insipidus is a rare disorder. It may be present at birth as a result of a sex-linked defect (congenital nephrogenic diabetes insipidus) that usually affects men, although women can pass the gene on to their children.

Most commonly, nephrogenic diabetes insipidus is an acquired disorder. Precipitating factors include drugs (lithium, demeclocycline, amphotericin B), electrolyte disorders (high calcium or low potassium levels), and urinary obstruction.

• Excessive thirst (may be intense or uncontrollable, with a craving for ice water)
• Excessive urine volume (may exceed 3 to 15 liters per day)

Inadequate fluid consumption can result in:

• Dehydration
  • Dry skin
  • Dry mucous membranes
  • Sunken appearance to eyes
  • Sunken fontanelles (soft spot) in infants
• Fatigue, lethargy
• Headache
• Irritability
• Low body temperature
• Muscle pains
• Rapid heart rate
• Weight loss

The goal of treatment is to regulate fluid levels in the body.

All cases should be treated with consistently high fluid intake. The volume of fluids consumed should approximately equal the volume of urine produced.

Reduction or discontinuation of medications that may cause nephrogenic diabetes insipidus may improve symptoms.

Hydrochlorothiazide may improve symptoms. This may be used alone or in combination with other medications, including indomethacin. Although this medication is a diuretic (these medications are usually used to increase urine output), hydrochlorothiazide can actually reduce the urine output for people with nephrogenic diabetes insipidus.

This medication works by causing sodium and water to be excreted in the early part of the renal tubules (the proximal tubules).

This leaves less fluid available for the late portion of the kidney (distal tubule) to excrete -- this is the portion affected by nephrogenic diabetes insipidus -- and thus it limits the total volume of urine that can be excreted.

• Severe dehydration, shock (if inadequate fluid intake)
• Hypernatremia (high blood sodium)
• Dilation of the ureters and bladder